An important class of heterocyclic chemicals are thiazole derivatives, providing a wide spectrum of biological activities in the form of antibacterial and antifungal, anti-HIV, anti-hypertensive, anti-inflammatory, anti-cancer, anti-convulsant, anti-depressant, and anti-tuberculosis acts. In this study we are prepared some novel derivatives from cetirizine impurity (A) by reacting 1-((4-chlorophenyl)(phenyl) methyl)piperazine with 2-chloro acetyl chloride to prepared 2-chloro-1-(4-((4-chlorophenyl) (phenyl) methyl)piperazin-1-yl)ethan-1-one (1) then reacting with 2-aminothiazole derivatives to prepare the derivatives (2-11) .The reaction was monitored by thin-layer chromatography (TLC) technique. All new compounds were characterized by melting points, elemental analysis, FT-IR, ¹H-NMR, and ¹³C-NMR spectroscopy. The molecular docking of these derivatives was also determined as anti-breast cancer by docking of prepared derivatives with (PDB:3eqm) protein by use (MOE 2015 program) and study of their efficient as antioxidant.