Synthesis of novel benzoannelated eight-membered heterocycles: easy access to benzo[f][1,4]oxazocin-1-ones

Jeanne-Marie Begouin; Stéphanie Hesse

doi:10.3390/ecsoc-10-01384

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Synthesis of novel benzoannelated eight-membered heterocycles: easy access to benzo[f][1,4]oxazocin-1-ones

Jeanne-Marie Begouin

Stéphanie Hesse

¹ Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Université Paul Verlaine - Metz, 1 Boulevard Arago, 57070 METZ, France

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-10-01384

Abstract: Medium-sized N-heterocycles, in particular eight-membered azocines, are key structures occurring in many natural products and in some compounds having biological activities. We described here an easy access to benzo[f][1,4]oxazocin-1-ones starting from 2-acetylbenzoic acid.

Keywords: eight-membered N, O heterocycles, ethanolamines, ZnCl<sub>2</sub>

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Jeanne-Marie Begouin

Stéphanie Hesse