New Synthesis of 4,4'-Diethylaminoethoxyhexestrol dihydrochloride (Coralgil) and scaling up to multi-grams scale

Behrooz Yousef; Ulrich Jordis Jordis

doi:10.3390/ecsoc-10-01415

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Probing The Resolution of 2-Alkoxy and 2-Aryloxy Carboxylic Acids

New Synthesis of 4,4'-Diethylaminoethoxyhexestrol dihydrochloride (Coralgil) and scaling up to multi-grams scale

Behrooz H. Yousef

Ulrich Jordis Jordis

¹ Institute of Applied Synthetic Chemistry, Vienna University of Technology, Austria

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-10-01415

Abstract: We report here new preparation with significant yield improvement of title compound. For this purpose the preparation of 4,4'-diethylaminoethoxyhexestrol dihydrochloride under different reported and analogue conditions have been tried. The optimized synthesis of Coralgil is reported. The synthesis was also scaled up to multi-grams for chemo-genomics study.

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Behrooz Yousef

Ulrich Jordis Jordis