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Probing The Resolution of 2-Alkoxy and 2-Aryloxy Carboxylic Acids
1 , 2 , * 2
1  Syngenta, Grangemouth Manufacturing Centre, Earls Road, Grangemouth, FX3 8XG, Scotland
2  Department of Chemistry, The University of Hull, Kingston Upon Hull, HU6 7RX, UK

Abstract: The separation of enantiomeric substrates using a parallel kinetic resolution strategy is becoming increasingly popular. 1 In recent years, attention has focussed on the use of traditional chiral auxilaries as complementary quasi-enantiomeric resolving agents. 2 In particular, Davies, 3 has elegantly shown the parallel kinetic resolution of the racemic enone (rac)-1 using a pair of quasi-enantiomeric lithium amides (S)-2 and (R)-3 to give the corresponding syn,syn,antiadducts 4 and 5 with near perfect levels of complementary stereocontrol (Scheme 1).
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