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Probing the Parallel Kinetic Resolution of Racemic Oxazolidinones using Quasi-enantiomeric Profens
1 , 1 , * 1, 2 , 3 , 3 , 1
1  Department of Chemistry, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
2  Department of Chemistry, The University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK
3  Onyx Scientific Limited, Units 97-98, Silverbriar, Sunderland Enterprise Park East, Sunderland, SR5 2TQ, UK

Abstract: The separation of enantiomeric substrates using a parallel kinetic resolution is becoming increasingly popular.1 In recent years, attention has focussed on the use of traditional chiral auxiliaries as complementary quasi-enantiomeric resolving agents. 2 In particular, Davies, 3 has elegantly shown the parallel kinetic resolution of the racemic enone (rac)-1 using a pair of quasi-enantiomeric lithium amides (S)-2 and (R)-3 to give the corresponding syn,syn,anti-adducts 4 and 5 with near perfect levels of complementary stereocontrol (Scheme 1).
Keywords: n/a