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Probing the Parallel Kinetic Resolution of Racemic Oxazolidinones using Quasi-enantiomeric Profens
Gregory S. Coumbarides
1 ,
Marco Dingjan
1 ,
Jason Eames
* 1, 2 ,
Tony Flinn
3 ,
Northern Northen
3 ,
Yonas Yohannes
1
1  Department of Chemistry, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
2  Department of Chemistry, The University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK
3  Onyx Scientific Limited, Units 97-98, Silverbriar, Sunderland Enterprise Park East, Sunderland, SR5 2TQ, UK
Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
https://doi.org/10.3390/ecsoc-10-01417
Abstract: The separation of enantiomeric substrates using a parallel kinetic resolution is becoming increasingly popular.1 In recent years, attention has focussed on the use of traditional chiral auxiliaries as complementary quasi-enantiomeric resolving agents. 2 In particular, Davies, 3 has elegantly shown the parallel kinetic resolution of the racemic enone (rac)-1 using a pair of quasi-enantiomeric lithium amides (S)-2 and (R)-3 to give the corresponding syn,syn,anti-adducts 4 and 5 with near perfect levels of complementary stereocontrol (Scheme 1).
Keywords: n/a
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