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Probing The Resolution of 2-Alkoxy and 2-Aryloxy Carboxylic Acids
Published:
30 November 2006
by MDPI
in The 10th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic Chemistry and Natural Products
Abstract: The separation of enantiomeric substrates using a parallel kinetic resolution strategy is becoming increasingly popular. 1 In recent years, attention has focussed on the use of traditional chiral auxilaries as complementary quasi-enantiomeric resolving agents. 2 In particular,
Davies, 3 has elegantly shown the parallel kinetic resolution of the racemic enone (rac)-1 using a pair of quasi-enantiomeric lithium amides (S)-2 and (R)-3 to give the corresponding syn,syn,antiadducts 4 and 5 with near perfect levels of complementary stereocontrol (Scheme 1).
Keywords: n/a