Innovative drug delivery systems show how pharmaceuticals are administered to the site of action that will produce the therapeutic effect. Fungal infections are a problem today on a global scale. There is no medical cover-up in the world regarding the significance of fungi as human pathogens. According to recent development, accurate diagnosis and treatment of these infections are crucial and required. Numerous factors influence the development of modern pharmaceutical products and the method of administration. Development of a successful novel antifungal drug delivery system, it is essential to thoroughly investigate the relationships between the formulations, mode of administration, pharmacological properties, pharmacokinetics, pharmacodynamics, stability, efficacy, safety, and clinical indications. This review article discusses various types of nano-particles used in the delivery of antifungal drugs, including dendrimers, polymeric nanoparticles, inorganic nanoparticles, and nano-particles based on phospholipids (nono-vesicles). Due to their unique properties, nano-particles can exert more inhibitory power through lower concentrations than conventional dosages when used in the treatment of fungal infections. Reduced drug efficacy, limited penetration through tissue, poor aqueous solubility, decreased bioavailability, and poor drug pharmacokinetics are among the drawbacks to using antifungal medications in delivery systems. Therefore, the in-corporation of antifungal medications through the nano-particles drug delivery system can reduce these undesirable properties.