Oral drug administration is among the most popular options in terms of patient compliance. The absorption window's influence enables the majority of commercially available modified-release dosage forms to have the desired physiological impact. In order to achieve the desired activity against the body's challenges, the formulator must keep the dosage form in the stomach, which is the aim of Gastro-retentive Drug Delivery (GRDD). In this process of maintaining in the Gastro Intestinal (GI) tract influenced by the nature of excipients driven by the type of formulation to achieve therapeutic goal, GRDD’s is comparable to improvised CDDS (Control Drug Delivery System). Control Delivery System before it reaches the absorption site. The most prevalent kind of preferred modified release system in use is solid oral dosage forms. To achieve the desired release profile, fewer doses are required when using these forms. Each drug candidate has a unique GIT absorption window, so there are many challenges. Solvability characteristics, pH-dependent variables, stability, physiological region, etc. Due to the barriers that have been added to this system, many products have been created. This review article contain nano-materials used in GRDD’s as novel drug delivery, factors affecting, challenges to formulate nano-materials, evaluation and advance technology used for application of nano-materials.