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Structure-Based Functional Annotation of an Uncharacterized Conserved Protein of Acinetobacter baumannii: An in-silico Approach
1 , 2 , * 3 , 4, 5
1  Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia-7003, Bangladesh
2  Department of Biotechnology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
3  Department of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh
4  Department of Biochemistry and Molecular Biology, Gono Bishwabidyalay, Dhaka-1344, Bangladesh
5  Department of Computational Biology and Bioinformatics, Advanced Bioscience Center for Collaborative Research (ABSCCR), Rajshahi 6250, Bangladesh
Academic Editor: Chi-Fai Chau


Acinetobacter baumannii (A. baumannii) is an example of an opportunistic pathogen that is generally harmless to healthy individuals but can cause serious infections such as ventilator-associated pneumonia, wound infections, and bacteremia’s in critically ill hospital patients. A. baumannii produces many proteins within its genome. By analyzing its structural as well as functional interpretation, bioinformatics techniques can make it easier to understand this organism. The protein is still unclear, though. As a result, in this study, an in-silico method for functional and structural characterization of the uncharacterized protein (accession ID: SSI32830.1) was developed. Many characteristics are provided by these in silico viewpoints, such as the protein's physiochemical qualities, sub-cellular localization, three-dimensional structure, and protein-protein interactions. Protein-protein interactions are explained using the STRING software. The projected tertiary structure evaluation was conducted using the Swiss Model. The best materials are chosen utilizing structural analyses based on Ramachandran plot analysis. This research sought to understand the function of A. baumannii. Therefore, this investigation will increase our understanding of pathophysiology and allow us to target the protein complex specifically.

Keywords: Acinetobacter baumannii; Uncharacterized protein; Protein modeling; Protein-protein interactions; computational research