Drought is a significant environmental stress that severely affects various key crops development, productivity, and overall quality. Recent studies have provided insight on the function of plant genetics in conferring drought stress resistance in tomato (Solanum lycopersicum), which is a key crop worldwide. In response to the need to mitigate the impacts of drought stress on tomato plants, it is focused on the assessment of the delicate interplay between genetic variables and microbial interactions. Some key genes, such as ABA-responsive genes, transcription factor genes, aquaporin genes, ROS-related genes, etc., and their function in drought tolerance in tomato plants have been discovered and analyzed to understand their role in stress adaptation. Additionally, Microbial interactions, notably with plant growth-promoting rhizobacteria (PGPR), mycorrhizal fungi, and pseudomonas, have emerged as key components in the context of drought stress alleviation. These helpful microbes develop symbiotic interactions with the tomato plant’s molecular functions, aiding nutrient intake, hormone control, and stress signal transmission. Moreover, their systemic resistance accelerates the plant's ability to cope with drought. This study emphasizes existing information on molecular principles underpinning stress tolerance and underscores the relevance of microbial-assisted stress amelioration and the interplay between genetic variables and microbial populations in relieving drought in tomato. Overall, it contributes to the necessity of understanding the intricate relationships between genetics and helpful microbes to create creative ways for sustainable agriculture in the face of growing water scarcity.