A potentially dianionic symmetric bisthiosemicarbazone ligand H₂L^Et has been prepared by a condensation reaction between two equivalents of 4-N-ethyl-3-thiosemicarbazide and one equivalent of 4,4’-methylenebis(acetophenone). The crystal structures obtained from solvents with different donor ability were studied. Recrystallization of H₂L^Et from methanol and dimethylsulfoxide allows the isolation of single crystals suitable for X-ray diffraction studies of [H₂L^Et] 1 and [H₂L^Et]·CH₃SOCH₃ 2, respectively. This study shows that the solvent does not affect the macrostructure but influences the microstructure of the ethyl-substituted bisthiosemicarbazone ligand H₂L^Et.