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A New Route for the Synthesis of Cyclic Thioureas and Related Compounds
1  Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Avenue 86, Moscow 117571, Russia

Abstract: Six-membered cyclic thioureas can be prepared by a convenient stereoselective method based on the reduction of readily available 4-hydroxy(or 4-alkoxy)hexahydropyrimidine-2-thiones or 1,2,3,4-tetrahydropyrimidine-2-thiones with NaBH4 - CF3COOH. Alternative method of the preparation of the target compounds includes reaction of 4-azido-, 4-acetoxy- or 4-arylsulfonylhexahydropyrimidine-2-thiones with NaBH4.
Keywords: hexahydropyrimidine-2-thiones/ones, 1,2,3,4-tetrahydropyrimidine-2-thiones, tetrahydro-1,3-thiazine-2-thiones, sodium tetrahydroborate - trifluoacetic acid