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A Coupling-Isomerization Sequence As An Entry To A Novel Three Component One-Pot Synthesis of 1,5-Benzoheteroazepines
Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: 2,4-Di(hetero)aryl substituted 2,3-dihydro 1,5-benzodiazepines, -oxazepines, and thiazepines can be readily synthesized in a three component one-pot process initiated by a coupling-isomerization sequence of an electron poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with 2-amino, 2-hydroxy, or 2-mercapto anilines.