Previous Article in event
Next Article in event
Benzylation of 2-Benzylisoindoline-1,3-diones via Photoinduced Electron Transfer. Photoinitiated Tin-Free Radical Additions to Cyclic Imides
Published: 01 November 2004 by MDPI in The 8th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Photoinduced electron transfer (PET) from arylacetates to 2-benzyl-isoindoline-1,3-diones (N-benzylphthalimides) in aqueous solution furnishes 3-benzylated 2-benzyl-3-hydroxyisoindolin-1-ones in high yields. The procedure constitutes an efficient photoinitiated tin-free radical alternative to the Grignard reaction en route to precursors to phenanthrene lactam alkaloids.