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Alpha Fluorination of Ketones by F+ Transfer Using a Precursor of MnF4
1 , 2 , * 3
1  Université Sidi Mohamed Ben Abdellah, Faculté des Sciences et Techniques, Laboratoire de Chimie Organique, Fès-Saïs 30000 Fès, Maroc
2  Université des Sciences et Technologies de Lille (Lille 1), Chimie Organique et Macromoléculaire, 59655 Villeneuve d’Ascq, France
3  Université Joseph Fourier (Grenoble 1), UREC-IMAG (150 rue de la Chimie) - BP53, 38041 Grenoble Cedex 9, France

Abstract: Alpha fluorination of ketones is carried out under very mild conditions by using manganese (IV) dioxide and pyridinium polyhydrogenofluoride. Working up is simple and yields are good. Results are consistent with the couple MnO2 / PyHF acting as a precursor of manganese (IV) tetrafluoride formed in situ.
Keywords: manganese (IV) dioxide; manganese (IV) tetrafluoride; alpha fluoroketones