Previous Article in event
Next Article in event
Substituted Pyrazinecarboxamides: Preparation and Biological Activity
Published: 01 November 2004 by MDPI in The 8th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: Newly synthesised pyrazinamide analogues with carboxamide moiety as a bridging ligands between basic and aromatic areas of molecule were tested for their antifungal and photosynthesis-inhibiting activity. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The highest antifungal effect (MIC < 62.5 µmol l-1) against Candida albicans, the most susceptible fungal strain tested, was found for 6-chloropyrazine-2-carboxylic acid (3-chlorophenyl)amide. The most active inhibitor of oxygen evolution rate in spinach chloroplasts was 5-tert-butyl-6-chloropyrazine-2-carboxylic acid (3-chlorophenyl)amide (IC50 = 47.0 µmol dm-3).
Keywords: substituted amides of pyrazin-2-carboxylic acid; antifungal evaluation; photosynthesis inhibition; spinach chloroplasts