Synthesis of 7-(10, 11-Dihydro-5H-dibenzo[a,d]-cyclo-hepten-5-ylamino)-heptanoicacid (Amineptine)

Klaus Gerdes; Shahzad Siddiqi; Jaywant Phopase; Ulrich Jordis

doi:10.3390/ecsoc-8-01974

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Synthesis of 7-(10, 11-Dihydro-5H-dibenzo[a,d]-cyclo-hepten-5-ylamino)-heptanoicacid (Amineptine)

Klaus Gerdes

Shahzad Siddiqi

Jaywant Phopase

Ulrich Jordis

¹ Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163 1060 Vienna, Austria

Published: 01 November 2004 by MDPI in The 8th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-8-01974

Abstract: This paper discribes the improved synthesis of 7-(10, 11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)-heptanoicacid (5) a synthetic, atypical tricyclic anti-depressant with central nervous system stimulating effects[1,2]. The synthesis was developed in context of the DrugMatrix[3] genomics project.

Keywords: n/a

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Klaus Gerdes

Shahzad Siddiqi

Jaywant Phopase

Ulrich Jordis