Synthesis of Sulfapyridine Metabolites

Petr Knesl; Ulrich Jordis

doi:10.3390/ecsoc-8-01975

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Synthesis of Sulfapyridine Metabolites

Petr Knesl

Ulrich Jordis

¹ Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria

Published: 01 November 2004 by MDPI in The 8th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-8-01975

Abstract: Sulfapyridine (SP) is an antibacterial compound that is used as such and also the active metabolite of sulfosalzazine (SASP) which shows antiphlogistic, antibacterial and immunomodulatoric properties. Sulfapyridine is also used to help control dermatitis herpetiformis (Duhring's disease), a skin problem. It has been reported, that sulfapyridine is metabolized to 5-hydroxysulfapyridine but no synthesis of this proposed metabolite has been published.We will report on the synthesis of thia and other potential metabolites of sulfapyridine.

Keywords: n/a

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Petr Knesl

Ulrich Jordis