Microwave Assisted and Conventional Mono Aryl Substitution of Diazabicycloalkanes by Palladium Coupling

Jaroslav Skubak; Behrooz Yousefi; Kishor More; Shahzad Siddiqi; Doris Domin; Jaywant Phopase; Ulrich Jordis

doi:10.3390/ecsoc-8-01990

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Microwave Assisted and Conventional Mono Aryl Substitution of Diazabicycloalkanes by Palladium Coupling

Jaroslav Skubak

Behrooz H. Yousefi

Kishor More

Shahzad A. Siddiqi

Doris Domin

Jaywant Phopase

Ulrich Jordis

¹ Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria

Published: 01 November 2004 by MDPI in The 8th International Electronic Conference on Synthetic Organic Chemistry session Symposium on Microwave Assisted Synthesis

https://doi.org/10.3390/ecsoc-8-01990

Abstract: The typical synthetic routes to the mono-aryl substituted piperazines are palladium catalyzed C-N coupling of piperazine or protected piperazines with aryl halides. In this work we describe the synthesis of aryl piperazines and aryl diazabicycles utilizing Pd catalyzed coupling reactions using protected and unprotected piperazines and diazobicycles performed both conventionally and by microwave assisted organic synthesis (MAOS).

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Jaroslav Skubak

Behrooz Yousefi

Kishor More

Shahzad Siddiqi

Doris Domin

Jaywant Phopase

Ulrich Jordis