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The Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intermolecular Cycloaddition
Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: The enantioselective synthesis of alpha amino acids which contain an additional chiral center at a remote position presents an important and complex synthetic problem. We have previously described the employment of a hetero Diels-Alder reaction for this purpose.1 In this project this methodology was notably extended, as demonstrated by the short synthesis of (2R,5R)-2-amino-4-hydroxyhexanoic acid.