Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N-Heterocyclic Carbenes derived from (S)-Pyroglutamic Acid

Giang Vo-Thanh; Audrey Aupoix; Chloée Bournaud

doi:10.3390/ecsoc-17-a005

Previous Article in event

PhSZn-Halides: New Green Thiolates

Next Article in event

Microwave Assisted Synthesis of 1-Allyl-3-Methylimidazolium Chloride

Next Article in session

Aluminium Sulfate is an Efficient and Mild Acid Catalyst for the One-pot, Four-Component Synthesis of 1,4-Dihydropyridine

Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N-Heterocyclic Carbenes derived from (S)-Pyroglutamic Acid

Giang Vo-Thanh

^*,

Audrey Aupoix

Chloée Bournaud

¹ University Paris-Sud

Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-17-a005

Abstract: A new and flexible procedure for the preparation of chiral azolium salts derived from (S)-pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal-catalyzed asymmetric transfer hydrogenation of aromatic ketones in iso-propanol. Good enantioselectivities up to 90% ee were observed.

Keywords: Asymmetric transfer hydrogenation, N-heterocyclic carbene, Aromatic ketones, (S)-pyroglutamic acid, Azolium salts

View paper

57 Reads
0 Recommendations

Giang Vo-Thanh

Audrey Aupoix

Chloée Bournaud