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Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N-Heterocyclic Carbenes derived from (S)-Pyroglutamic Acid
Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A new and flexible procedure for the preparation of chiral azolium salts derived from (S)-pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal-catalyzed asymmetric transfer hydrogenation of aromatic ketones in iso-propanol. Good enantioselectivities up to 90% ee were observed.
Keywords: Asymmetric transfer hydrogenation, N-heterocyclic carbene, Aromatic ketones, (S)-pyroglutamic acid, Azolium salts