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Aluminium Sulfate is an Efficient and Mild Acid Catalyst for the One-pot, Four-Component Synthesis of 1,4-Dihydropyridine
Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Aluminium sulfate has mild acidity, yet the acidity of aluminium sulfate is not taken advantage of in organic synthesis. Here, we utilized aluminium sulfate for the first time in a multicomponent reaction for the synthesis of 1,4-dihydropyridine. A four-component one-pot synthesis of 1,4-dihydropyridine was carried out by condensing aromatic aldehyde, 2equivalent of ethyl acetoacetate, and ammonium acetate using a catalytic amount of aluminium sulfate (10%) refluxed in ethanol. The present protocol using aluminium sulfate a mild solid catalyst has several merits, such as low cost, high yield, and shorter reaction time, with no byproducts.
Keywords: Aluminium sulfate, Dihydropyridine, Ethyl acetoacetate, 1,4-dihydropyridine, Four components.