Abstract: Metal nanoparticles, due to their unusual properties especially the high surface-to-volume ratio than bulk metal has recently become the focus of intense work. Physical and chemical properties of the particles differ considerably differ from those of the compact solids. On the other hand quinazolinone derivatives are fused organic aza-heterocyclic compounds which have attracted considerable attention, because they exhibits a wide range of biological properties such as anti-cancer, anti-inflammatory, anti-convulsant and anti-hypertensive activities. In view of the biological importance of quinazoline and its derivatives, several synthetic strategies have been employed including the reactions of anthranilamide with aldehyde derivatives using acids catalyst. In this research, we have used composite metal-graphene-based nanocatalyst to produce different derivatives of dihydroquinazolines in mild reaction conditions and with easy, simple and economical work-up procedure in good-to-high yields. Also the catalysts could be recycled and reused several times without considerable reduction in its activity.