Please login first
Fe3O4@ ZrO2/SO42- as a Nano Magnetic Solid Acid Catalyst for one Pot Synthesis of Benzylamino Coumarin Derivatives
* , ,
1  Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114

Abstract: In this research, a new strategy has been introduced for the synthesis of a series of benzylamino coumarin derivatives. Coumarin and its derivatives are an important class of heterocyclic compounds, which constitute the key core of various natural products. These compounds also exhibit a wide band of biological activities including anti-HIV, antimalarial, insecticides, and antioxidants, antibacterial, antiviral, anticoagulant and anticancer activities. Also these compounds have been used in important clinical applications such as Warfarin, Phenprocoumon, Coumatetralyl, Carbochromen, Bromadialone. Nano magnetic sulfated zirconia (Fe3O4@ZrO2/SO42-) can be used as a magnetic solid acid catalyst for the synthesis of benzylamino coumarin derivatives by the reaction of 4-hydroxycoumarin, cyclic secondary amine and aromatic aldehyde at room temperature in acetonitrile. The catalyst (Fe3O4@ZrO2/SO42-) could be easily separated by the use of an external magnetic field and recycled and reused several times without considerable reduction in its activity.
Keywords: Nano magnetic sulfated zirconia; Benzylamino coumarin; 4-hydroxycoumarin