This research investigates innovative nanostructure-enhanced voltammetric biosensing platforms developed for rapid medical diagnostics. Our laboratory has engineered electrochemical sensors incorporating advanced nanomaterials, including graphene oxide composites, multi-walled carbon nanotubes, and functionalized gold nanoparticles, demonstrating remarkable improvements in analytical performance metrics compared to traditional diagnostic approaches. The developed point-of-care devices target clinical settings, demanding rapid diagnostic capabilities. These portable systems integrate sophisticated artificial intelligence frameworks, facilitating automated signal processing, pattern classification, and comprehensive clinical decision assistance. Advanced machine learning algorithms enable patient risk assessment, personalized therapeutic guidance, and predictive modeling for disease trajectory analysis. Our nanostructure-modified electrodes exhibit enhanced sensitivity, improved selectivity, and accelerated response kinetics for biomarker quantification. The electrochemical detection platform provides precise, real-time measurements applicable to bedside testing scenarios. Computational intelligence integration supports automated result interpretation and clinical correlation analysis. Key innovations include device miniaturization, cost-efficient manufacturing, and simplified operational protocols. The portable architecture facilitates deployment across varied healthcare environments, from specialized medical centers to resource-limited settings. Automated data processing minimizes user intervention while maximizing diagnostic accuracy. This intelligent biosensing technology represents transformative advancement toward individualized healthcare and targeted diagnostic approaches. Ongoing developments encompass regulatory compliance strategies, manufacturing scale-up initiatives, and seamless integration with digital health platforms for continuous patient surveillance and chronic condition management.