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Synthesis of L-Carnosine and its Applications in Biomedical Field
1 , * 1 , 2
1  Department of Chemistry, Iran University of Science and Technology
2  Member of the World Society of the Anti-Aging Medicine and International Hormone Society, Niavaran, Tehran, Iran

Abstract: Chelation therapy is the administration of chelating agents to remove heavy metals from the body. Chelation therapy has a long history of use in clinical toxicology. For the most common forms of heavy metal intoxication – lead, arsenic, or mercury. a number of chelating agents are available are Ethylenediaminetetraacetate (EDTA), Dimercaptosuccinic acid (DMSA), 2,3-dimercapto-1-propanesulfonic acid (DMPS), alpha lipoic acid (ALA) and Carnosine. their used in conventional and alternative medicine. In this work synthesise of Carnosine has been studied. Carnosine (beta-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. Carnosine is found naturally in healthy muscles, heart, brain, liver, kidneys and other tissues. N-Protected amino acids are important intermediates in organic synthesis. The use of N-phthalylamino acids as coupling agents in the synthesis of peptides has been studied by several groups of investigators. hydrolysis of the phthalyl group with hydrazine at room temperature affords a direct synthesis of L-Carnosine. The molecular structures of the compounds were definite by using UV-Vis, FT-IR, and 1H NMR spectroscopy.
Keywords: Chelation therapy; L-Carnosine; Phthalyl-β-alanyl; Histidine