Today sensor data processing and information mining become more and more complex concerning the amount of sensor data to be processed, the data dimension, the data quality, and the relationship between derived information and input data. This is the case especially in large-scale sensing and measuring processes embedded in Cloud environments. Measuring uncertainties, calibration errors, and unreliability of sensors have a significant impact on the derivation quality of suitable information. In the technical and industrial context the raising complexity and distribution of data processing is a special issue. Commonly, information is derived from raw input data by using some kind of mathematical model and functions, but often being incomplete or unknown. If reasoning of statements is primarily desired, Machine Learning can be an alternative. Traditionally, sensor data is acquired and delivered to and processed by a central processing unit. In this paper, the deployment of distributed Machine Learning using mobile Agents forming self-organizing and self-adaptive systems (self-X) is discussed and posing the benefit for the enhancement of the sensor and data processing in technical and industrial systems. This also addresses the quality of the computed statements, e.g., an accurate  prediction  of run-time parameters like  mechanical loads or health conditions, the efficiency, and the reliability in the presence of partial system failures.