Synthesis and Cytotoxic Evaluation of Constrained Analogues of Combretastatin and Combretastatin A4.

Pierre Grandclaudon; Eric Deniau; Axel Couture; Vangelis Agouridas; Magali Lorion

doi:10.3390/ecsoc-14-00410

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Synthesis of optically active derivatives of bicyclic chiral diols with C2 symmetry

Synthesis and Cytotoxic Evaluation of Constrained Analogues of Combretastatin and Combretastatin A4.

Pierre Grandclaudon

Eric Deniau

Axel Couture

^*,

Vangelis Agouridas

Magali Lorion

¹ Université Lille Nord de France, F-59000 Lille, France
² USTL, Laboratoire de Chimie Organique Physique, EA CMF 4478, Bâtiment C3(2), F-59655 Villeneuve d'Ascq, France
³ CNRS, UMR 8181 'UCCS', F-59655 Villeneuve d'Ascq, France

Published: 20 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-14-00410

Abstract: A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.

Keywords: combretastatins, isoindolinones, oxygen heterocycle, oxidation, anticancer agents.

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Pierre Grandclaudon

Eric Deniau

Axel Couture

Vangelis Agouridas

Magali Lorion