Previous Article in event
Next Article in event
Cycloaddition of Methyl Acrylate with Substituted Pyridinium-3-olates and Pyrazinium-3-olates: 1,3-Dipolar Cycloaddition versus Diels-AlderNext Article in session
Synthesis and Cytotoxic Evaluation of Constrained Analogues of Combretastatin and Combretastatin A4.
Published: 20 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.
Keywords: combretastatins, isoindolinones, oxygen heterocycle, oxidation, anticancer agents.