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Highly Efficient Three-Component Strecker-Type Reaction of Aldehydes and Ketones Using TMSCN Catatalyzed by Recyclable and Heterogeneous Mesoporous B-MCM-41
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1  Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran

Abstract: Mesoporous Borosilicate (B-MCM-41) efficiently catalyzed the three-component Strecker-type reaction of different amines and aldehydes or ketones with trimethylsilyl cyanide (TMSCN) in CH2Cl2 at room temperature to afford the corresponding α-aminonitriles in excellent yields. The catalyst can be recovered and reuse for at least 5 reaction cycles without significant lose of its reactivity.
Keywords: Carbonyl Compounds; Amine; Trimethylsilyl Cyanide (TMSCN); α-Aminonitriles; Mesoporous Materials