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Synthesis of 5-amino-α-D-gluco-hept-6-enfuranose as usefull 1-deoxynojirimycin precursor using [3,3]-sigmatropic aza-Claisen rearrangement
Published: 31 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Iminosugars are one of the most interesting discoveries in the field of natural products recent years due to their promissing biological activity. We report synthesis of 1-deoxynojirimycin building block using D-glucose as the starting material and the [3,3]-sigmatropic aza-Claisen rearrangement as the key step of our synthesis.
Keywords: 1-deoxynojirimycin, azasugars, aza-Claisen rearrangement