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Preparation of (5S)-5-C-methyl-β-L-lyxo-hexofuranose derivative as(+)-lactacystin precursors
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1  Department of Organic Chemistry, Institute of Chemical Science, Faculty of Science, P.J. Šafárik University in Košice, Moyzesova 11., 040 67, Košice, Slovakia

Abstract: We present here the preparation of the precursor for stereoselective synthesis of (+)-lactacystin starting from D-glucose. The first step is conversion of D-glucose to 1,2:5,6-di-O-isopropylidene-α-D-gulofuranose. The second step is introduction of a methyl group at C5 and preparation of compound 9. This compound can be used as a precursor of target molecule of (+)-lactacystin
Keywords: Lactacystin, Asymetric synthesis, Proteasome inhibitor