One-pot three-component Mannich-type reaction catalyzed by functionalized ionic liquid

Ali Sharifi; Mohammad Naimi-Jamal; Amene Yaghoubi

doi:10.3390/ecsoc-14-00458

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One-pot three-component Mannich-type reaction catalyzed by functionalized ionic liquid

Ali Sharifi

¹,

Mohammad Reza Naimi-Jamal

^{*

2},

Amene Yaghoubi

¹ Chemistry & Chemical Engineering Research Center of Iran, Tehran 14968-13151, IRAN
² Research Laboratory of Green Organic Synthesis, Department of Chemistry, Iran University of Science and Technology, Tehran 16846, Iran

Published: 30 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-14-00458

Abstract: Several ionic liquids used as catalyst for three-component Mannich reactions of aldehydes, amines, and naphthols at room temperature. The used ionic liquids include 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄), 1-octyl-3- methylimidazolium tetrafluoro-borate ([Omim]BF₄), 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF₄), butyl dimethylimidazolium tetrafluoroborate ([Bdmim]BF₄), 1-octyl-3-methylimidazolium nitrate ([Omim]NO₃), 1-methylimidazolium sulfuric acid ([Hmim]HSO₄) and 1-methylimidazolium trifluoroacetic acid ([Hmim] Tfa). Higher yields were obtained in the presence of [Hmim]Tfa in comparison with other ionic liquids.

Keywords: One-pot, three-component, Mannich-type. ionic liquid

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Ali Sharifi

Mohammad Naimi-Jamal

Amene Yaghoubi