The role of excipients in neglected tropical diseases

¹ Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon yCajal s/n, Madrid, 28040, Spain.
² 3Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, Moncada, Valencia, 46113, Spain.
³ School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael’s Building, White Swan Road, Portsmouth PO12DT, U.K.

Published: 13 October 2017 by MDPI in MOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed. congress NANOBIOMAT-03: Nanotechnology & Biomaterials Sci. Congress, Jackson & Fargo, USA, 2017

https://doi.org/10.3390/mol2net-03-04621

Abstract:

Leishmaniasis is a neglected tropical disease responsible for the ninth largest disease burden in the world. Excipients are necessary for ensuring the stability and bioavailability of currently available antileishmaniasis drugs. In a recent work, we have evaluated the in vitro activity of 30 commercially available excipients against different Leishmania spp., their cytotoxicity and potential use for inclusion in novel formulations. Ref: Curr Top Med Chem. 2017 Jul 19. https://www.ncbi.nlm.nih.gov/pubmed/28730958

Keywords: Excipients, leishmaniasis, amphiphile, surfactant, lipids, Eudragit, Labrasol, medium chain fatty acids, lauric acid, sodium deoxycholate

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