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Investigation of the Appel reaction with bromotrichloromethane-triphenylphosphine (CBrCl3/PPh3)
Published:
03 November 2017
by MDPI
in The 21st International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
The Appel reaction of an alcohol with CCl4/PPh3 and with CBr4/PPh3 produce alkyl chlorides and alkyl bromides, respectively. It was found that in the case of using CBrCl3-PPh3, a mixture of alkyl chlorides and alkyl bromides are formed. Dichloromethane (CH2Cl2) and acetonitrile (CH3CN) were used as solvents, where the reaction was found to be solvent-dependent.
Keywords: Appel reaction, bromotrichloromethane, alkyl halide
