The Appel reaction of an alcohol with CCl4/PPh3 and with CBr4/PPh3 produce alkyl chlorides and alkyl bromides, respectively. It was found that in the case of using CBrCl3-PPh3, a mixture of alkyl chlorides and alkyl bromides are formed. Dichloromethane (CH2Cl2) and acetonitrile (CH3CN) were used as solvents, where the reaction was found to be solvent-dependent.
Previous Article in event
Next Article in event
Microwave-assisted embedding of bis-vanillin and bis-eugenol into SBA-15: Synthesis of chemosensors precursors for the detection of metal cationsNext Article in session
Investigation of the Appel reaction with bromotrichloromethane-triphenylphosphine (CBrCl3/PPh3)
Published: 03 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: Appel reaction, bromotrichloromethane, alkyl halide