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Synthesis and Biological Activity of Some New Heterocyclic Compounds
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1  Chemistry department, faculty of science, Suez Canal University, Ismailia, Egypt

Abstract: 5-(3,5-Dibromo-2-hydroxyphenyl)-2,3,4-trihydro-1,2,4-triazole-3-thione(4) and 3-[(5-bromo-or 3,5-dibromo-2-hydroxy-phenylmethylene)-amino]-4-oxo-imidazolinidin-2-thiones(7a,b)were prepared via the reaction of 2,3,5trisubstituted benzaldehyde thiosemicarbazones(2a,b)with bromine in acetic acid and ethylchloroacetate in presence of fused sodium acetate. While 5-(4-methylphenyl-2-[3,5-dibromo-2-hydroxy-phenylmethylene)-hydrazion]-thiazole(5) prepared via reaction of (2b) with 4-methyl phenacylbromide. Acylation of (2b) and (5) with acetic anhydride gave the corresponding diacetyl derivatives (3) and (6).
Keywords: thiosemicarbazone; thiazole; imidazolidin-2-thione; acylation; bromination