Notes Towards a Network Approach to Gene Orientation

¹ RNASA-IMEDIR, Computer Science Faculty, University of A Coruña, 15071, A Coruña, Spain
² Universidad Estatal Amazónica
³ Dept. of Organic Chemistry II, University of the Basque Country UPV/EHU, 48940, Leioa, Biscay, Spain

Published: 19 December 2017 by MDPI in MOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed. congress CHEMBIOMOL-03: Chem. Biol. & Med. Chem. Workshop, Rostock, Germany-Bilbao, Spain-Galveston, Texas, USA, 2017

https://doi.org/10.3390/mol2net-03-05092

Abstract:

The distribution of the orientation genes in chromosomes is not random and may have function implications. In this work, we used complex networks to study the orientation of genes. We used as a case of study the 14 chromosomes of Plasmodium falciparum. We constructed the respective 14 networks with an average of 383 nodes (genes) and 1314 links (pairs of gene with inverse orientation). Node centralities of these nodes were used to study the structure of the network.

Keywords: Malaria; Plasmodium sp. proteome; Chromosome microstructure; Gene orientation; Complex Networks; Machine Learning

View Poster

176 Reads
0 Recommendations

Viviana Quevedo

Bernabé Ortega-Tenezaca

Julio César Vargas-Burgos

Alejandro Pazos-Sierra

Humbert González-Díaz