In the current study, we have isolated and characterized a novel molecule from the hard shell of Cocos nucifera Linn. and evaluated it for its inhibitory potential against hyaluronidase enzyme. Alcoholic extract of the hard shell was subjected to various purification procedures viz. column chromatography, solvent based extraction and TLC to yield a phytomolecule. Spectral characterization indicated that it is a novel keto fatty acid. To the best of our knowledge, this is the first keto fatty acid from the coconut plant even. Results of hyaluronidase inhibition assay indicated that it has moderate hyaluoronidase inhibitory activity.
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Isolation of Novel Hyaluronidase Inhibitor from the Hard Shell of Coconut
Published: 11 July 2018 by MDPI in MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed. congress CHEMBIOINFO-04: Chem-Bioinformatics Congress Cambridge, UK-Chapel Hill and Duluth, USA, 2018
Keywords: Hyaluronidase inhibitor; Cocos nucifera; Natural product