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Isolation of Novel Hyaluronidase Inhibitor from the Hard Shell of Coconut
1 , 2 , * 3
1  Division of Biological Sciences an Engineering, Netaji Subhas Institute of Technology, Sector-3, Dwarka, New Delhi-110078, India
2  Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India
3  Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi 110078, India


In the current study, we have isolated and characterized a novel molecule from the hard shell of Cocos nucifera Linn. and evaluated it for its inhibitory potential against hyaluronidase enzyme. Alcoholic extract of the hard shell was subjected to various purification procedures viz. column chromatography, solvent based extraction and TLC to yield a phytomolecule. Spectral characterization indicated that it is a novel keto fatty acid. To the best of our knowledge, this is the first keto fatty acid from the coconut plant even. Results of hyaluronidase inhibition assay indicated that it has moderate hyaluoronidase inhibitory activity.

Keywords: Hyaluronidase inhibitor; Cocos nucifera; Natural product