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Inhibition of Staphylococcus aureus and its biofilm by the metabolites of endophytic Streptomyces sp. ADR1
1 , * 2
1  Division of Biological Sciences an Engineering, Netaji Subhas Institute of Technology, Sector-3, Dwarka, New Delhi-110078, India
2  Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi 110078, India


Staphylococcus aureus is a gram positive, tissue colonizer pathogen in humans. It is known for its tendency to build up biofilm which is a major cause of antibiotic resistance. To overcome this problem, there is an urgent requirement to discover novel antimicrobial compounds against new bacterial targets and drug resistance. In this direction the actinobacteria inhabiting special niche like plant tissues can be promising agents for novel compounds against methicillin sensitive and resistant S. aureus (MRSA).

The ethyl acetate extract of Streptomyces sp. ADR1 is found to be a strong inhibitor of various Staphylococcus sp. and its resistant strain MRSA with very low MIC90 values; <31.25 µg/ml. The extract was found to inhibit biofilm formation as well as preformed biofilms of S. aureus and MRSA to a significant extent.

Keywords: Antibacterial agents; MRSA; Biofilm