Biological activity of two new imidazole-based Cu(II) frameworks resulting from a one-pot reaction

¹ Laboratoire des Structures, Propriétés et Interactions Interatomiques LASPI2A, Département des Sciences de la Matière, Faculté des Sciences et de la Technologie, Université ‘’Abbes Laghrour’’, Khenchela 40.000, Algeria
² Departamento de Química Física y Analítica, Universidad de Oviedo – CINN, 33006 Oviedo, Spain
³ Department of Chemistry, Faculty of Science, Cumhuriyet University 58140 Sivas, Turkey
⁴ Dipartimento di Scienze Chimiche e Geologiche, Università di Modena e Reggio Emilia & INSTM, via G. Campi 103, 41125 Modena, Italy
⁵ Department of Chemistry, Federal University Otuoke, P.M.B 126, Yenagoa, Bayelsa State, Nigeria

Published: 16 November 2018 by MDPI in 4th International Electronic Conference on Medicinal Chemistry session ECMC-4

https://doi.org/10.3390/ecmc-4-05859

Abstract:

Imidazole occurs in most proteins as part of the side chain of histidine and constitutes a binding site for various transition metal ions in a large number of metalloproteins [1]. Consequently, the bonding between imidazole and transition metal ions is widely known [2] and of considerable interest especially in biological systems [3,4]. Consequently, copper(II)–imidazole systems with different ratios of imidazole to copper have been prepared and investigated by several researchers [5]. Moreover, being studied as models for copper proteins that contain both functionalities in the side chain [6], some mononuclear copper(II)–imidazole complexes with carboxylate ligands have been found to display a variety of pharmacological effects, including antitumor [7], superoxide dismutase and catecholase activities [8]. In order to contribute to the study of these systems, we have synthesized two new penta-coordinated copper(II) complexes with mixed-ligands, namely: imidazole and citric acid. The resulting compounds have shown remarkable antimicrobial and antifungal inhibition activities, which have been predicted by exploring the computational chemical reactivity of the two complexes [9].

References :

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[9] Direm, A. Abdelbaky, M. S. M. Sayın, K. Cornia, A. Abosede, O. & García-Granda, S. (2018). Inorg. Chim. Acta. 478. 59–70.

Keywords: Imidazole-based complexes, Cu(II) frameworks, one-pot synthesis, crystal structure, ab-initio calculations, biological properties.

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