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Antimicrobial and anticancer activities of bisacodyl and it’s deacetylated metabolite DDPM
* 1, 2 , 1 , 2 , 1 , 2 , 1
1  Equipe de Chimie Moléculaire du Laboratoire CMGPCE, EA 7341, Conservatoire national des arts et métiers, 2 rue Conté,75003, HESAM Université, Paris France
2  Laboratoire de Biotechnologie Microbienne et d’Ingénierie des Enzymes (LBMIE). Centre de Biotechnologie de Sfax, Université de Sfax, Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax, Tunisie


The antibacterial activity of a bisacodyl and its deacetylated metabolite, DDPM was investigated against Gram-positive pathogens including Staphylococcus aureus (ATCC 9144), Micrococcus luteus (LB14110), Salmonella enterica (NCTC 6017) with minimum inhibitory concentration (MIC) ranging from 12.5 to 25 µg/mL, 6.25 to 12.5 µg/mL and 25 to 50 µg/mL respectively. The results of antibacterial activity against Gram-negative foodborne Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739), show MIC values between 12.5 -25 μg/mL and 25-50 μg/mL. The antifungal activity was also evaluated against the opportunistic pathogenic yeast Candida albicans (ATCC 2091) with MIC ranging from 12.5 to 25 µg/mL. Furthermore, the anticancer activity was evaluated against epithelial cervical cancer cell line (ATCC, Manassas,VA, USA). The results obtained indicated that bisacodyl and its deacetylated metabolite, DDPM have a cytotoxic activity at 63.69 µg/mL and 16.7 µg/mL respectively.

Keywords: Bisacodyl, DDPM, antibacterial activity, antifungal, anticancer