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Synthesis and characterization of new biocompatible amino amphiphilic compounds derived from oleic acid as nanovectors for drug delivery
Victoria Valdivia Giménez * , Chiara Paggiaro, Inmaculada Fernández
1  Departamento de Química Orgánica y Farmacéutica. Facultad de Farmacia. Universidad de Sevilla. C/ Profesor García González 2, 41012 Seville, Spain

10.3390/ecsoc-23-06458
Abstract:

Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble to form different types of macromolecular structures such as micelles, monolayer vesicles, bars, sheets and tubes. In this work, a convergent synthetic approach for the synthesis of two new amphiphilic compounds based on a versatile amino polar head, a tetraethylene glycol spacer and a lipophilic tail derived from oleic acid has been developed. Subsequently, after a self-assembly process in aqueous medium, nanostructures as micelles have been obtained and characterized. Finally, a procedure for the inclusion of the highly lipophilic drug Dexamethasone has been carried out in order to study the ability of these micelles to act as nanovectors for drug delivery.

Keywords: amphiphilic compounds, self-assembly, nanovectors, drug delivery
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