A new series of 5-acetylbarbituric based thiosemicarbazones has been synthesized from 5-acetylbarbituric acid and unsubstituted/substituted thiosemicarbazides (1-6). The synthesized compounds were well characterized by elemental analyses, FT-IR, 1H, 13C NMR and mass spectroscopic methods. Three dimensional molecular structure of three compounds (1, 2 and 6) was determined by single crystal X-ray crystallography. The compounds were evaluated for their in vitro cytotoxicity against HeLa-229 cancer cell line.
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Synthesis and characterization of some 5-acetylbarbituric based thiosemicarbazone derivatives.
Published: 14 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: Thiosemicarbazones; 5-acetylbarbituric acid; heterocyclics; single crystal, cytotoxicity