A serie of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-b-carbolines were synthesized via a one pot Ugi-azide/Pictet–Spengler process under mild ultrasound-assisted conditions. The products containing two privileged heterocyclic frameworks: 1,5- disubstituted-1H-tetrazole and tetrahydro-b-carboline, which are present in a variety of bioactive compounds and commercial drugs.
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Synthesis of the 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-b-carbolines via ultrasound-assisted one-pot Ugi-azide/Pictet–Spengler process
Published: 14 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: Ugi-azide/Pictet–Spengler; ultrasound-assisted; 1,5- disubstituted-tetrazole; b-carboline