Synthesis of the 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-b-carbolines via ultrasound-assisted one-pot Ugi-azide/Pictet&ndash;Spengler process

MANUEL ALEJANDRO RENTERIA GOMEZ; MARIA DEL ROCÍO GÁMEZ MONTAÑO

doi:10.3390/ecsoc-23-06515

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Synthesis of the 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-b-carbolines via ultrasound-assisted one-pot Ugi-azide/Pictet–Spengler process

MANUEL ALEJANDRO RENTERIA GOMEZ

MARIA DEL ROCÍO GÁMEZ MONTAÑO

¹ Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química

Published: 14 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-23-06515

Abstract:

A serie of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-b-carbolines were synthesized via a one pot Ugi-azide/Pictet–Spengler process under mild ultrasound-assisted conditions. The products containing two privileged heterocyclic frameworks: 1,5- disubstituted-1H-tetrazole and tetrahydro-b-carboline, which are present in a variety of bioactive compounds and commercial drugs.

Keywords: Ugi-azide/Pictet–Spengler; ultrasound-assisted; 1,5- disubstituted-tetrazole; b-carboline

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MANUEL ALEJANDRO RENTERIA GOMEZ

MARIA DEL ROCÍO GÁMEZ MONTAÑO