The catalytic application of a novel magnetic periodic mesoporous organosilica functionalized 3-propylamine(Fe3O4@PMO-ICS-PrNH2) in the synthesis of imidazopyrimidine derivatives was investigated. At first, the Fe3O4@PMO-ICS-PrNH2 nanocatalyst was prepared and characterized by N2 adsorption-desorption isotherms techniques, field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy and vibrating sample magnetometer (VSM). Then, the catalyst was shown to be a efficient recyclable and highly active catalyst and used in the three-component synthesis of 2-aminobenzaldehyde with aromatic aldehydes various and dimedone/malononitrile under H2O solvent conditions. Also, imidazopyrimidine products were obtained in mild reaction conditions, good to excellent yields and at short reaction times. Moreover, the catalyst was recovered and successfully reused at least five times without considerable reduction in its activity.