The catalytic application of a novel magnetic periodic mesoporous organosilica functionalized 3-propylamine(Fe₃O₄@PMO-ICS-PrNH₂) in the synthesis of imidazopyrimidine derivatives was investigated. At first, the Fe₃O₄@PMO-ICS-PrNH₂ nanocatalyst was prepared and characterized by N₂ adsorption-desorption isotherms techniques, field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy and vibrating sample magnetometer (VSM). Then, the catalyst was shown to be a efficient recyclable and highly active catalyst and used in the three-component synthesis of 2-aminobenzaldehyde with aromatic aldehydes various and dimedone/malononitrile under H₂O solvent conditions. Also, imidazopyrimidine products were obtained in mild reaction conditions, good to excellent yields and at short reaction times. Moreover, the catalyst was recovered and successfully reused at least five times without considerable reduction in its activity.