Synthesis of pyrrolidinols by radical additions to carbonyls groups

Francesca Marini; Martina Palomba; Luana Bagnoli; Claudio Santi

doi:10.3390/ecsoc-23-06606

Previous Article in event

Convenient Synthesis of Some Novel 4-Benzyl-1(2H)-Phthalazinone Derivatives of expected anticancer activity

Next Article in event

Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles

Next Article in session

Synthesis of Some new phthalizine dione derivatives with their anti-microbial and anti-cancer activity

Synthesis of pyrrolidinols by radical additions to carbonyls groups

^{*

1},

²,

¹,

¹ Department of Phamaceutical Sciences, University of Perugia
² Department of Pharmaceutical Sciences, University of Perugia

Published: 14 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-23-06606

Abstract:

Radical cyclizations are considered efficient synthetic strategies to assembly heterocycles. Most radical cyclizations are based on the addition to C-C double or triple bonds. On the contrary, the addition to C-O double bonds is rarely reported, since it proceed reversibly due to the formation of thermodynamically unfavorable alkoxy radicals. Herein we report our attempts to construct substituted pyrrolidin-3-ols by tin-mediated radical cyclization of 5-phenylseleno-3-aza-pentanals. These rings are widely represented in natural products and drug candidates with various biological activities.

Keywords: Selenium; Cyclizations; Pyrrolidines; Radicals.

View paper

47 Reads
0 Recommendations