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Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles
* 1 , 2 , * 3 , 3 , 4 , 5
1  Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt
2  Department of Chemistry, Faculty of Science, king Khalid university, KSA
3  National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Egypt
4  Department of Pharmacology, Medical Division, National Research Center,
5  Biomedical Sciences Department, University of Science & Technology, Zewail City of Science & Technology, Giza, 12588, Egypt


Background: A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.

Results: In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.

Conclusion: The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.

Keywords: 1, 3, 4-thiadiazoles, fused imidazoles, heterocyclic amines, microwave irradiation, anti-inflammatory, analgesic and anti-ulcer agents.