Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles

Sobhi Gomha; Mastoura Edrees; Zeinab Muhammad; Hatem Gaber; Mohamed Amin; Islam Matar

doi:10.3390/ecsoc-23-06607

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Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles

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¹ Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt
² Department of Chemistry, Faculty of Science, king Khalid university, KSA
³ National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Egypt
⁴ Department of Pharmacology, Medical Division, National Research Center,
⁵ Biomedical Sciences Department, University of Science & Technology, Zewail City of Science & Technology, Giza, 12588, Egypt

Published: 14 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry

https://doi.org/10.3390/ecsoc-23-06607

Abstract:

Background: A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.

Results: In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.

Conclusion: The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.

Keywords: 1, 3, 4-thiadiazoles, fused imidazoles, heterocyclic amines, microwave irradiation, anti-inflammatory, analgesic and anti-ulcer agents.

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