Please login first
Ionic liquid mediated Ugi/SN2 Cyclization: Synthesis of 1,2,3-Triazole containing novel 2,5-diketopiperazines.
* , , *
1  Centro Conjunto de Investigacion en Química Sustentable UAEM-UNAM, Toluca, Estado de Mexico, Mexico.
2  Facultad de Quimica , Universidad Autonoma del Estado de Mexico


The Ugi four-component reaction is versatile multicomponent reaction for generation of complex diversity, herein we used 4-((1-((tetrahydrofuran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde as one of the components in Ugi 4CR that contains 1,2,3- triazole moiety which is a privileged molecule in medicinal chemistry to obtain Ugi adducts under room temperature ionic liquids [BBIM]BF4 as medium of solvent, then followed SN2 pathway cyclization to get triazole containing 2,5-diketopiperazine derivatives in good yield using basic ionic liquids[BBIM]OH as a catalyst

Keywords: Ugi multicomponent reaction, Task-specific Ionic Liquid. 1,2,3 triazole, 2,5-diketopiperazine.