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Thiohydantoins from vanillin and its derivatives - Synthesis and Characterization
1 , 2 , 1 , 3 , * 3
1  Faculty of Science, University of Kragujevac, Radoja Domanovića 12 P.O. Box 60, 34000 Kragujevac, Serbia
2  Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
3  Institute for Information Technologies Kragujevac, Department of Science, University of Kragujevac, Jovana Cvijica bb, 34000 Kragujevac, Serbia

Abstract:

Hydantoins and their sulfur containing analogues, thiohydantoins, are an important and interesting moiety. They represent a big group of structurally diverse compounds with intriguing physical, chemical and biological properties, which enabled them to be used in therapy, medicine in general, material science and industry.

With the goal of broadening the set of potentially applicable hydantoin derivatives, we have synthesized a series of 2-thiohydantoins from vanillin and its derivatives, which themselves posses interesting biological properties. All compounds were fully characterized by NMR and IR spectroscopy. The compounds will be subjected to intensive biological screening to determine their biological properties and application opportunities.

Keywords: thiohydantoins; synthesis; vanillin;
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