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Cytokine Storm in COVID-19: a severe immune situation
Italo Rossi Roseno Martins
* 1 ,
Joedna Cavalcante Pereira
2
1  Campus Senador Helvídio Nunes de Barros, Universidade Federal do Piauí (UFPI), Picos, Piauí, Brazil.
2  Unidade Descentralizada do Iguatu, Universidade Regional do Cariri (URCA), Iguatu, Ceará, Brazil.
Published: 06 July 2020 by MDPI in MOL2NET'20, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 6th ed. congress CHEMBIOMOL-06: Chem. Biol. & Med. Chem. Workshop, Bilbao-Rostock, Germany-Galveston, Texas, USA, 2020
https://doi.org/10.3390/mol2net-06-06873 (registering DOI)
Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) is responsible for the greatest pandemic of the 21st century. Since December 2019 until now more than nine millions have been infected by the virus and almost five hundred thousand people lost their lives for Coronavirus disease 2019 (COVID-19). Some mechanisms were associated to COVID-19 pathophysiology and specially in severe cases a specific dysregulation in the immune system could be identified, the cytokine storm. In that situation occurs a decrease in the anti-inflammatory and protective imune compounds and an increase in peripheral blood of pro-inflammatory, such as interleukin-2 (IL-2), IL-6, IL-10 and interferon-gamma (IFN-γ) that cause lung injury and worsens the patient's prognosis. So, this work aimed to review the role played by cytokine storm in SARS-CoV-2 infection, in order to to better understand the molecular events behind out-of-control cytokine response in severe COVID-19 patients.

Keywords: coronavirus; SARS; cytokine release syndrome
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Comments on this paper
Rajeev K Singla
4 January 2021
Informative Piece of Work #COVID-19
Cytokine storm is the major challenge faced by clinicians while dealing with the COVID-19 patients. Authors have summarized the scientific facts and figures associated with cytokine storm in COVID-19 in proper way. Thanks for sharing this scholarly contribution.
Alejandro Speck-Planche
10 January 2021
Comments on cytokine storm (COVID-19)
The authors have correctly described some of the molecular targets involved in the cytokine storm. To the best of my knowledge other targets such as IL-1 and TNF-alpha have also been identified as key players in the cytokine storm. Could you give your opinion on the role of these two proteins?


 
 
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